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    patent summary: "dressings and methods related thereto". The present invention relates to dressings, such as an adhesive bandage, which may have an absorbent pad, and a non-sticky film attached thereto having at least two different polymeric materials, a first polymeric material and a second polymeric material having a lower melting point than the first polymeric material.
    公开号:BR112013031188B1
    申请号:R112013031188-6
    申请日:2012-06-04
    公开日:2019-10-01
    发明作者:Ajit K. Moghe；Richard E. Gahan；Harish A. Patel
    申请人:Kpr U.S., Llc；
    IPC主号:
    专利说明:

    DRESSING FOR A WOUND APPLICATION AND ITS PRODUCTION METHOD
    BACKGROUND
    Technical Field [001] The present disclosure relates in general to dressings, and, more particularly, to dressings and adhesive bandages for wounds that include a non-sticky film having a plurality of polymeric materials with different melting points or bands of melting, for example, a first polymeric material with a first melting point or melting range and a second polymeric material with a second melting point or melting range less than the first melting point or melting range.
    Description of the Related Technique [002] Karami et al., In US Patent 5,167,613, disclosed a composite of ventilated wound dressing, which dressing is to be placed first on the skin to cover a wound and a secondary dressing to serve as a top layer containing a absorbent pad to receive and retain fluids from the wound that diffuse into it from the wound.
    [003] Patel, in US Patent 5,465,735 disclosed a wound dressing with an absorbent pad to receive and retain wound fluids sandwiched between first and second outer sheet materials. The first sheet material for placing on the wound may be a perforated non-stick film to prevent the dressing from sticking to the wound. The second sheet material can be characterized as being impervious to bacteria.
    [004] Patel, in US Patent 5,632,731, disclosed a non-adherent wound dressing with a multi-layer absorbent pad comprising an inner layer of a low-density absorbent material to receive fluids that diffuse from the wound and an overlapping layer of a high-density absorbent material to receive and retain wound fluids that diffuse through the inner layer.
    SUMMARY
    Petition 870190061452, of 7/1/2019, p. 10/41
    2/27 [005] One or more aspects of the invention can be directed to a dressing for application to a wound. According to one or more embodiments of such aspects of the invention, the dressing may comprise an absorbent pad having a wound-facing surface and a second surface opposite the wound-facing surface, and a non-sticky film attached to the absorbent pad on the surface. facing the wound, the non-sticky film having a first region comprising a first polymeric material and a second region comprising a second polymeric material having a lower melting point than that of the first polymeric material. The first polymeric material may comprise, consist essentially of emem, or consist of a first thermoplastic polymer selected from the group consisting of polypropylene, vinylidene polyfluoride, polytetrafluoroethylene, polyvinyl chloride, polyamide, polyethylene, polyvinyl alcohol, polyester, polystyrene, polymethylpentene, polyoxymethylene , and mixtures thereof, the second polymeric material may comprise, consist essentially of, or consist of a second thermoplastic polymer selected from the group consisting of polypropylene, vinylidene polyfluoride, polytetrafluoroethylene, polyvinyl chloride, polyamide, polyethylene, polyvinyl alcohol, polyester , polystyrene, polymethylpentene, polyoxymethylene, and mixtures thereof; and the second region can define a fixing layer that holds the non-sticky film on the wound-facing surface of the absorbent pad, or can be attached to this film. The dressing may further comprise a second film attached to an absorbent pad on its second surface. The second film can have a third region comprising the first polymeric material and a fourth region comprising the second polymeric material. According to other variants of these modalities, the fourth region can define a second fixing layer that secures the second film to the second surface of the absorbent pad, or can be attached to this second film. The first polymeric material can consist of or consists essentially of a first polyester and the second polymeric material can consist of or consists
    Petition 870190061452, of 7/1/2019, p. 11/41
    3/27 essentially in a second polyester. The second polymeric material can comprise an amorphous polymer having a melting temperature range of about 120 ° C to about 200 ° C. The first polymeric material can comprise or consist essentially of polyethylene terephthalate having a melting temperature range of about 200 ° C to about 275 ° C. The second polymeric material can comprise or consist essentially of a polyethylene terephthalate with a glass transition temperature in the range of about 60 ° C to about 88 ° C. The dressing can further comprise a support substrate having an adhesive material on a surface thereof. According to a variant of this modality or modalities, the support substrate can be attached to the absorbent pad on the second surface. The supporting substrate may comprise or consist essentially of a cloth and the adhesive material may comprise or consist essentially of an acrylic. The non-sticky film may have one or more perforated regions, each of which has a plurality of perforations that extend through the thickness of the film. The absorbent pad may comprise a fiber selected from the group consisting of cellulosic fibers such as viscose, cotton, paper pulp in fiber, and lyocell and polymeric fibers such as polypropylene, and polyester fibers, as well as combinations thereof. The absorbent pad may have a first absorbent layer comprising, consisting essentially of, or consisting of a low density absorbent cloth and a second conduction layer comprising, consisting essentially of, or consisting of a high density absorbent cloth. The dressing may further comprise at least one therapeutic agent in any of the absorbent pad and the non-sticky film. In one or more variants of one or more embodiments of the invention, the absorbent pad may comprise polyhexamethylene biguanide (PHMB).
    [006] One or more aspects of the invention can be directed to a method of producing a dressing. The method of producing the dressing can
    Petition 870190061452, of 7/1/2019, p. 12/41
    4/27 is intended to provide a non-sticky film having a first region comprising a first polymeric material and a second region comprising a second polymeric material having a lower melting point than the first polymeric material, and fixing the non-sticky film on an absorbent pad. on a surface facing the wound. Attaching the non-sticky film to the absorbent pad may comprise enclosing the absorbent pad within a wrapper comprising the non-sticky film. Fixing the non-sticky film to the absorbent pad may comprise melting at least a portion of the second polymeric material. Fixing the non-sticky film to the absorbent pad may comprise exposing the non-sticky film to an environment with a temperature in the range of about 140 ° C to about 200 ° C. The method of producing the dressing can further comprise attaching the absorbent pad to a supporting substrate having an adhesive material on a surface thereof. The first polymeric material can have a melting range ranging from about 200 ° C to about 275 ° C, and, according to other embodiments of the invention, the second polymeric material can have a melting range ranging from about 120 ° C to about 200 ° C. The first polymeric material may comprise, consist essentially of, or consist of a first thermoplastic polymer selected from the group consisting of polypropylene, vinylidene polyfluoride, polytetrafluoroethylene, polyvinyl chloride, polyamide, polyethylene, polyvinyl alcohol, polyester, polystyrene, polymethylpentene, polyoxymethylene, and mixtures thereof. The second polymeric material may comprise, consist essentially of, or consist of a second thermoplastic polymer selected from the group consisting of polyamide, polyethylene, polyvinyl alcohol, polyester, polystyrene, polymethylpentene, polyoxymethylene, and mixtures thereof. The first polymeric material can consist essentially of a first polyester having a melting range of about 200 ° C to about 275 ° C and the second polymeric material can essentially consist of a second polyester having a melting range ranging from about 120 ° C to about 200 ° C. O
    Petition 870190061452, of 7/1/2019, p. 13/41
    5/27 absorbent pad may have a first absorbent layer comprising or essentially consisting of a low density absorbent cloth and a second conduction layer comprising or consisting of a high density absorbent cloth. Attaching the non-sticky film to the absorbent pad may comprise securing the second region of the non-sticky film to the second conduction layer of the absorbent pad. The method may further comprise introducing at least one therapeutic agent into the absorbent pad or the non-sticky film. The introduction of the minimal therapeutic agent may comprise immersing at least part of the absorbent pad in a fluid comprising polyhexamethylene biguanide to produce a pad immersed in PHMB; and drying the pad immersed in PHMB to produce a pad containing PHMB. In one or more embodiments of the invention, fixing the non-sticky film to the absorbent pad may comprise fixing the second region of the non-sticky film to the pad containing PHMB.
    BRIEF DESCRIPTION OF THE DRAWINGS [007] The present disclosure will be more clearly understood from the following description together with the accompanying drawings in which:
    [008] FIG. 1 is a plan view of an adhesive bandage, according to at least one embodiment described here;
    [009] FIG. 2 is an elevation view of the adhesive bandage shown in FIG. 1;
    [0010] FIG. 3 is a plan view of a dressing, according to at least one embodiment described here;
    [0011] FIG. 4 is an elevation view of the dressing shown in FIG. 3, and further showing an absorbent pad between a non-sticky film and a second film;
    [0012] FIG. 5 is a plan view of an adhesive bandage, according to at least one embodiment described here; and [0013] FIG. 6 is an elevation view of the adhesive bandage shown Petition 870190061452, from 7/1/2019, p. 14/41
    6/27 of in FIG. 5.
    DETAILED DESCRIPTION [0014] One or more aspects of the invention can be directed to dressings and bandages that are typically applied to cuts, abrasions, and wounds to collect blood and other exudates from the wound. One or more aspects of the invention can be directed to improving the adhesion of a non-sticky film or resistant adhesive layer to an absorbent pad of bandages and bandages. One or more aspects of the invention can be directed to increase the absorption capacity of blood, wound exudates, or other dressing fluids and bandages while reducing the likelihood of separation or separation on non-film sheets sticky from the absorbent pad. Yet one or more other aspects of the invention can be directed to providing non-sticky films on one wound side of the bandages and bandages, and an adherent surface or layer on the side of the bandages and bandages that is not facing the wound. One or more other aspects of the invention may be aimed at facilitating the bonding of a non-sticky film onto an absorbent pad of bandages and bandages, which may allow the bandage or bandage to withstand greater stresses associated with a bleeding and / or discharge wound. .
    [0015] According to one or more embodiments of the invention, a dressing can comprise at least one absorbent pad having a bottom part, or a first surface, attached to a support material or substrate and an upper part, typically a more close to a wound, or facing a wound, and a non-sticky film having a non-wound side positioned near the top, or fixed on the first surface, of the absorbent pad, as well as a wound-facing side, which it is intended to be against or facing the wound. The non-sticky film may comprise a first region comprising, consisting essentially of, or consisting of a
    Petition 870190061452, of 7/1/2019, p. 15/41
    7/27 first polymeric material and a second region comprising, consisting essentially of, or consisting of a second polymeric material. The first and second polymeric materials can be combined in a multilayered configuration so that the first and second polymeric materials can be combined to form a single or unitary layer. In some embodiments of the invention, the non-sticky film may comprise a first region having a greater amount of the second polymeric material with respect to an amount of the first polymeric material, and a second region with a higher amount of the first polymeric material with respect to a amount of the second polymeric material, thereby defining a gradient of polymeric material over or through at least a part of the non-sticky film. According to some embodiments of the invention, the first and second polymeric materials can include or be based on the same type of polymer, but have different melting points, melting bands, softening points, or softening bands. According to some embodiments of the invention, the first and second polymeric materials may comprise, consist essentially of, or consist of polyesters, but have different melting ranges, softening points, or softening bands. According to some specific embodiments of the invention, the second polymeric material can have a lower melting point than the melting point of the second polymeric material. According to some specific embodiments of the invention, the second polymeric material can have a lower melting point or melting temperature range that is less than the lower melting point or melting temperature range of the first polymer. According to some embodiments of the invention, the first polymeric material can have a melting temperature range and the second polymeric material can have a melting temperature range that has an initial melting temperature which is at a lower temperature than melting temperature range of the first polymeric material.
    [0016] According to some modalities of the invention, the bandage
    Petition 870190061452, of 7/1/2019, p. 16/41
    The adhesive may comprise a support material or substrate, an adhesive applied to the support material or substrate, an absorbent pad having a bottom part attached to the support material or substrate and an upper part closer to an injury, and an non-sticky film with a non-wound surface positioned close to or attached to the top, or a first surface of the absorbent pad, and a wound-facing surface that is intended to be wound-facing when in use. The non-sticky film may comprise a first polyester having a first melting point, or a first melting temperature range, and may further comprise a second polyester having a second melting point, or a first melting temperature range, so that the first melting point or range is greater than the second melting point or range. In other cases, at least a part of the first melting temperature range is greater than at least a part of the second melting temperature range.
    [0017] In any of the various modalities disclosed here, the non-sticky film can have a thickness in a range of about 10 microns to about 50 microns. Typically, the non-sticky film has a uniform thickness profile.
    [0018] At least a portion of the non-sticky film may have a perforated region having a plurality of perforations or openings through the thickness of the film. When used, the second film may have a perforated region with a plurality of perforations or openings. Perforations can be evenly distributed over the minimum portion of the non-sticky film. In a variant of these modalities, the density of the perforations can be varied. Typically, the perforated region has a perforation density in the range of about 300 perforations per square inch to about 400 perforations per square inch. Each of the plurality of perforations can have any geometric shape, but each typically has a circular profile. The size of any of the perforations can
    Petition 870190061452, of 7/1/2019, p. 17/41
    9/27 vary and be in a range of about 0.01 mm to 1 mm; typically, perforations have a nominal diameter in the range of about 0.5mm to about 1mm.
    [0019] The non-sticky film typically includes at least one first polymeric material and a second polymeric material in which the first and second polymeric materials have different melting points. The non-sticky film can be composed of any suitable polymeric material capable of not adhering to the wound or wound exudates. In some particularly useful embodiments, the non-sticky film may include a first layer comprising a first polymeric material and a second polymeric material having a melting point or melting range less than the melting point or melting range of the first polymeric material. In some variations of some embodiments of the invention, the second polymeric material has a melting point or melting range that ranges from about 120 ° C to about 200 ° C. In some other variations of some embodiments of the invention, the second polymeric material has a melting point or melting range that ranges from about 200 ° C to about 275 ° C. Some non-limiting examples include polyesters, such as polytetrafluoroethylene and polyethylene terephthalate, polyolefins, based on polyethylene, polypropylene, 4-methylpentene-1, and combinations thereof. In some embodiments of the invention, the first polymeric material comprises a polyethylene terephthalate, such as, for example, an amorphous polyethylene terephthalate having a melting point below about 200 ° C and the second polymeric material comprises crystalline polyethylene terephthalate or hair. less partially crystalline having a melting point or melting range greater than that of the first polymeric material. In particularly useful embodiments of the invention, the non-sticky film may include a first layer comprising a polyethylene terephthalate having a melting point less than or equal to about 200 ° C, and a second layer comprising a polyethylene terephthalate having a melting point in a range of about 200 ° C to about 275 ° C.
    Petition 870190061452, of 7/1/2019, p. 18/41
    According to other aspects of the invention, the first region of the non-sticky film may have a glass transition temperature that differs from the glass transition temperature of the second region of the non-sticky film. For example, the non-sticky film may have a region comprising, consisting essentially of, or consisting of a polymeric material with a glass transition temperature in the range of about 60 ° C to about 88 ° C, and in some cases , may have yet another region comprising, consisting essentially of, or consisting of another polymeric material with another higher glass transition temperature. In some embodiments of the invention, the non-sticky film region may comprise, consist essentially of, or consist of at least partially crystalline polymeric material, and at least partially amorphous polymeric material. For example, the first region may comprise, consist essentially of, or consist of at least partially crystalline, polymeric material; and the second region may comprise, consist essentially of, or consist at least partially of, at least partially amorphous polymeric material. In some configurations or variations thereof, for example, the non-sticky film may have a gradient of decreasing crystallinity from the first region to the second region. In some other configurations or variants thereof, the non-sticky film may have, for example, an increasing gradient from an amount or level of amorphous polymer from the second region to the first region.
    [0021] In some particular modalities of dressings or bandages, the thickness of the amorphous layer can be at least about 25 microns, and can be in a range of about 25 microns to about 100 microns.
    [0022] In embodiments in which the same polymeric material is used to form the non-sticky films described here, the melting point can be changed or adapted by using polymeric materials with different molecular weights. In the modalities, the difference in the melting points
    Petition 870190061452, of 7/1/2019, p. 19/41
    11/27 The first and second polymeric materials used to form the non-sticky film can range from about 1 to about 100 degrees Celsius, from about 5 to about 50 degrees Celsius, and still in other embodiments, from about 10 to about 25 degrees Celsius [0023] The non-sticky film can be a multilayer film including at least two layers, wherein one layer, typically the layer closest to the absorbent pad, is made of a polymeric material having a dot melting point than that of other polymeric material in another layer that is closer to the wound. It is anticipated that the multilayer film may be exposed to the appropriate heat at a temperature that will soften or melt at least a portion of the film, thus facilitating the adhesion of the non-sticky film to the absorbent pad, while maintaining the capacity of the film. non-sticky film does not adhere to the wound during use. For example, the non-sticky film may have a first layer that comprises, consists essentially of, or consists of an amorphous polyester having a melting point, melting temperature range, or softening point of at least about 200 ° C, in some cases, at least about 225 ° C and, in some advantageous configurations, it may have a melting temperature range ranging from about 200 ° C to about 275 ° C. The second layer may comprise, consist essentially of, or consist of a polyester having a melting point, melting temperature range, or softening point of less than about 225 ° C, in some cases, less than about 200 ° C and, in some advantageous configurations, may have a melting temperature range ranging from about 120 ° C to about 200 ° C.
    [0024] During production, any of the non-sticky film or films can thus be adhered to the pad or any of the absorbent pads by raising the temperature of at least a part of the non-sticky film until the conditions or environments of the melting temperature , such as a temperature in the range of about 140 ° C to about 200 ° C
    Petition 870190061452, of 7/1/2019, p. 20/41
    12/27 to at least partially melt or soften at least part of the second layer; then cooling down to approximately room temperature to adhere the non-sticky film to the absorbent pad. Unlike adhesives, the first polymeric layer will remain after being combined with the absorbent pad. According to some embodiments of the invention, the non-sticky film, the absorbent pad, or both, can be heated so that at least the melting or softening of at least a part of the second polymeric material occurs. In some embodiments, the absorbent pad and the non-sticky film can be heated with ultrasound. For example, the lamination of any film or any of the films, or any portion thereof, or any absorbent pad or pads, or a portion thereof, may be carried out using ultrasonic energy at a frequency that promotes sufficiently thermal bonding by melting or softening at least a part of the polymeric material. The ultrasonic frequency can be at least about 20 kHz, for example, in a range of about 20 kHz to 100 kHz, and is typically around 20 kHz or about 70 kHz. According to some embodiments of the invention, the absorbent pad and the non-sticky film can be heated using gamma radiation. The resistance to flaking between the minimum portion of the film or non-sticky films and the absorbent pad or pads, for samples with the width of an inch, can be in a range of about 10Og / inch to about 1000g / inch as determined by flaking of the pellet film at a separation speed of about 12 inches per minute, at 25 ° C and a humidity of 65%.
    [0025] The dressings and bandages described here may also include a second film, such as one positioned between the supporting substrate and the absorbent pad. In embodiments like this, the first non-sticky film may be affixed to the bottom side of the absorbent pad and the second film may be affixed to the supporting substrate, for example,
    Petition 870190061452, of 7/1/2019, p. 21/41
    13/27 by using an adhesive. In embodiments like this, the additional film can increase the ability of the dressing or bandage to store more wound exudates without increasing the possibility of the dressing or bandage to adhere to the wound. Both the second film and the additional film can be attached to the absorbent pad or any other component or substrate of the dressing or bandage by using the same technique that would be used to attach the film or non-sticky films.
    [0026] According to some embodiments of the invention, any of the films may further comprise fibers and / or additional components. Some non-limiting examples of techniques that can be used to manufacture the various films include extrusion, spraying, shaping or molding.
    [0027] The supporting material or substrate can be made of any material suitable for covering wounds. Non-limiting examples of the support substrate include polymeric films, paper substrates, woven fabrics, and non-woven fabrics. Examples of polymeric films as well as techniques for making such films that can be used as supporting substrates are disclosed, for example, in US Patent 6,326,081 B1, the full disclosure of which is incorporated herein by reference. According to some embodiments of the invention, the supporting substrate can be made of at least one thermoplastic polymer. According to some embodiments of the invention, the supporting substrate can be made of at least one thermosetting polymer. Suitable thermoplastic polymers may include, but are not limited to, polyolefins, such as low density polyethylene and linear low density polyethylene, polyvinyl alcohol, nylon, polyester, polystyrene, polymethylpentene, polyoxymethylene, and combinations or mixtures thereof. In one or more embodiments of the invention, the support substrate can include an elastic polymer. Suitable elastic polymers include, but are not limited to, metallocene-catalyzed ethylene copolymers together with a comonomer selected from the group consisting of octene, hexene, and butene; polymers of ethylene propylene diene monomer, styrene polymers, such as
    Petition 870190061452, of 7/1/2019, p. 22/41
    14/27 such as, among others, styrene-butadiene-styrene and styrene-ethylene-butylene copolymers; copolymers of ethylene methyl acrylate; polymers of ethylene vinyl acetate, and mixtures thereof. A mixture of any of the thermoplastic, thermoset and elastic polymers can be used as well.
    [0028] The support substrate described here can be formed using any suitable method. For example, the supporting substrate can be extruded, molded, modeled with solvent, woven or braided. In other configurations, the supporting layer or substrate may be a non-woven component.
    [0029] In some embodiments of the invention, the supporting substrate, or at least a portion thereof, may be perforated or perforated to provide, for example, fluid permeability through it, from one surface to an opposite surface. In some embodiments of the invention, the supporting substrate may have one or more sides in relief. For example, one side or surface of the supporting substrate can be smooth and the other side or surface has a matte finish.
    [0030] One or more absorbent pads can be used in one or more modalities described here. Absorbent pads or pads can protect the wound from contamination by dirt and can collect blood, wound exudates, and other fluids. The pad or any of the absorbent pads may be made of natural materials, synthetic materials, or combinations thereof, including, for example, natural fibers, such as, but not limited to, cotton and wood pulp fibers, and synthetic fibers, such as , for example, polyester fibers, polyamide, and polyolefin. In some particular configurations, the absorbent pad or pads may comprise, consist essentially of, or consist of cotton. In other particular embodiments of the invention, the absorbent pad or pads comprise, consist essentially of, or consist of rayon fibers. Synthetic fibers comprising two or more polymers can be used. Mixtures of various qualities or types of fibers can be used in which
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    15/27 or one or more of the embodiments of the invention. For example, the absorbent pad or pads may be made of a mixture of fibers including a first set of fibers made of viscose and a second set of fibers made of a polyester. In addition, any of the fibers can be two-component fiber. For example, one or more of the fibers may have a core composed of a material, such as a first polymer, and a cap, in at least a portion of the core, composed of a second material, such as a second polymer or a different polymer . Any of the fibers can have any suitable denier to, for example, collect a desired amount of fluid. For example, the linear mass density of the fiber or any of the fibers in the minimum absorbent pad may be in the range of about 1 to 100 denier.
    [0031] The absorbent pad or pads used in the various dressings and bandages may have a porosity that is adequate to allow the pad to collect and retain fluids. Any portion of the pad is expected to be porous. The pad or any of the pads may have uniform porosity, a random degree of porosity, or may have a porosity gradient that, in some cases, can facilitate fluid management, such as fluid flow in the pad. pad. The pores of the absorbent pad or any of the absorbent pads can be created using any suitable method. For example, the absorbent pad or any of the absorbent pads may include woven, non-woven fibers, or mixtures thereof, in which the space between the fibers creates porosity. According to other embodiments of the invention, the absorbent pad or any of the absorbent pads may comprise a foam material. For example, any of the materials described here can be placed in a solution and lyophilized or freeze dried to form a foam.
    [0032] According to some embodiments of the invention, the absorbent pad or any of the absorbent pads may have a plurality
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    16/27 of characteristics or properties. For example, the absorbent pad may have at least two regions or portions, such as layers, with different properties. Non-limiting examples of the various different properties include density, porosity, diffusivity, and absorbency or absorptive capacity. In one or more embodiments of the invention, the absorbent pad may comprise, consist essentially of, or consist of two or more regions, such as layers, of woven fibers. In one or more embodiments of the invention, the absorbent pad may comprise, consist essentially of, or consist of two or more regions, such as layers, of non-woven fibers. In one or more embodiments of the invention, the absorbent pad may comprise, consist essentially of, or consist of a first region or layer with a low density material, and a second region or layer with a high density material. In one or more embodiments of the invention, the absorbent pad may comprise, consist essentially of, or consist of a first region or absorbent layer comprising a low density cloth, and a second region or conduction layer comprising a high density cloth. In one or more embodiments of the invention, the absorbent pad may comprise, consist essentially of, or consist of an absorbent region or layer of woven fibers, non-woven fibers, or both. In one or more embodiments of the invention, the absorbent pad may comprise, consist essentially of, or consist of a conducting region or layer of woven fibers, non-woven fibers, or both. The absorbent region or layer typically has a greater fluid absorptive capacity than the conduction region or layer. The conduction region or layer typically has a higher fluid diffusivity rate than the diffusion rate of the absorbent region or layer.
    [0033] In some cases, the absorbent pad may comprise or consist of a third region, such as a layer, comprising, consisting essentially of, or consisting of any of the fibers
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    17/27 woven, non-woven fibers, or combinations thereof. In some embodiments of the invention, the third region or layer may have at least one characteristic that is similar to that of any of the region or absorbent layer and the conduction region or layer. For example, the third region may have the same or approximately the same absorptive capacity as the absorbent region; or the third region may have the same or approximately the same fluid diffusivity as the conduction region. In some embodiments of the invention, the third region may have one or more characteristics that are between the characteristics of the first region and the second region. The third region can be close to any of the first and second regions, and can be arranged between the first and second regions. In some configurations, the third region can be arranged in a position that is distal from the first region, thus disposing the second layer between the first and the third region. For example, the absorbent pad may comprise, consist essentially of, or consist of a first absorbent region, a second conduction region disposed against a first side or surface of the absorbent region, and a third conduction region disposed against a second side or surface of the absorbent region, distal or opposite to the first side or surface.
    [0034] The absorbent pad may be adapted to provide one or more properties or characteristics of the aggregate. For example, any of the relative amounts of each layer of the absorbent pad may be varied. According to some embodiments of the invention, the ratio of the thickness of a layer to another layer of the absorbent pad may be in the range of about 1: 1 to about 7: 1. For example, the ratio of the thickness or relative quantity of the absorbent layer to the thickness or relative quantity of the conduction layer can be in the range of about 3: 1 to about 5: 1. In some particular embodiments of the invention, the ratio of the thickness or relative quantity of the absorbent layer to the thickness or relative quantity of the conduction layer can be in a
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    18/27 range from about 2: 1 to about 4: 1, in some cases, in a range from about 2.5: 1 to about 3.5: 1.
    [0035] Any of the absorbent pads may have any desired base weight and are typically in a range, for example, from about 0.001 g / cm 2 to about 0.25 g / cm 2 . In addition, the size of any of the absorbent pads may vary depending on several considerations including, for example, the size of the dressing or bandage, and the size of the wound to be protected or treated. In any of the various embodiments of the invention, at least a portion of the absorbent pad may have a density in the range of about 0.1 to about 0.3 g / cm 3 . In addition, in any of the various embodiments of the invention, the minimum portion of the absorbent pad may have a density in a range of less than about 0.1 g / cm 3 . In some embodiments of some embodiments of the invention, the absorbent layer can have a density in the range of about 0.01 g / cm 3 to about 0.05 g / cm 3 . The absorbent pad may have about 3 ounces per square yard of surface area up to about 10 ounces per square yard of surface area. In some embodiments of some embodiments of the invention, the absorbent pad may have about 7 ounces per square yard of surface area.
    [0036] The absorbent pad may include at least one therapeutic agent. A therapeutic agent is a compound that can provide a therapeutic or prophylactic effect. Some examples of the minimal therapeutic agent include compounds that effect or participate in one or more of tissue growth, cell growth, and cell differentiation. In addition, at least one therapeutic agent can be an anti-adhesive compound, or a compound that can bring about a biological action, such as an immune response, or participate in one or more biological processes. The therapeutic agent can be applied to and / or incorporated into the pad, or any other part of the dressing or adhesive bandage described here in any suitable manner, for example, films, powders, liquids and gels.
    Petition 870190061452, of 7/1/2019, p. 27/41
    19/27 [0037] Examples of classes of therapeutic agents, which can be used in accordance with the present disclosure include antiadhesives, antibacterial agents, antimicrobial agents, antibiotic agents, antifungal agents, antiviral agents, anticoagulants, anticonvulsants, antidepressants, analgesics, antipyretics , anesthetics, antiepileptics, antihistamines, anti-inflammatories, cardiovascular drugs, diagnostic agents, sympathomimetics, cholinomimetics, antimuscarinics, antispasmodics, hormones, growth factors, muscle relaxants, adrenergic neuron blockers, antineoplastics, immunogenic agents, immunogenic agents, immunogenic agents, immunogenic agents, immunogenic agents, immunogenic agents, immunogenic agents, immunogenic agents, immunogenic agents, immunogenic agents, immunogenic agents, immunogenic agents, immunogenic agents, immunogenic agents, immunogenic agents, immunogenic agents, immunogenic agents and gastrointestinal drugs, diuretics, steroids, lipids, lipopolysaccharides, polysaccharides, drugs that activate platelets, clotting factors, and enzymes. It is also intended that combinations of therapeutic agents can be used.
    [0038] Antimicrobial agents, antifungal agents, antiseptic agents, or antibiotic agents, which may be included as the minimum therapeutic agent include, for example, polyhexamethylene biguanides (PHMB); trichloro or 2,4,4'-trichloro-2'-hydroxydiphenyl ether, chlorhexidine and salts thereof, including chlorhexidine acetate, chlorhexidine gluconate, chlorhexidine hydrochloride and chlorhexidine sulfate; silver and salts or complexes thereof, including silver acetate, silver benzoate, silver carbonate, silver citrate, silver iodide, silver iodide, silver lactate, silver laurate, silver nitrate, silver oxide, palmitate silver, silver protein, and silver sulfadiazine; polymyxin, tetracycline; aminoglycoside antibiotics, such as, but not limited to, tobramycin and gentamycin; rifampicin; bacitracin; neomycin; chloramphenicol; miconazole; fluorquinolone and quinolone-based agents such as oxolinic acid, norfloxacin, nalidixic acid, pefloxacin, enoxacin and ciprofloxacin; penicillins such as oxacillin and pipracil; nonoxynols; fusidic acid, cephalosporins; and combinations thereof. In addition, antimicrobial proteins and peptides such as bovine lactoferrin and lactoferricin B can be used as the minimal therapeutic agent. According to some mo
    Petition 870190061452, of 7/1/2019, p. 28/41
    20/27 particular conditions, any of the bandages or adhesive bandages described here includes polyhexamethylene biguanide.
    [0039] Other therapeutic agents can be local anesthetics; non-steroidal antifertility agents; parasympathomimetic agents; psychotherapeutic agents; tranquilizers; decongestants; sedative hypnotics; steroids; sulfonamides; sympathomimetic agents; vaccines; vitamins; antimalarians; anti-migraine agents; antiparkinson agents such as L-dopa; antispasmodics; anticholinergic agents; agents such as oxybutynin; cough eliminators or antitussive agents; bronchodilators; cardiovascular agents such as coronary vasodilators and nitroglycerin; alkaloids; painkillers; narcotics such as codeine; dihydrocodeinone, meperidine, and morphine; non-narcotic agents such as salicylates, aspirin, acetaminophen, and d-propoxyphene; opioid receptor antagonists such as naltrexone and naloxone; anti-cancer agents; anticonvulsants; antiemetics; antihistamines; anti-inflammatory agents such as hormonal agents, hydrocortisone, prednisolone, prednisone, non-hormonal agents, allopurinol; indomethacin; phenylbutazone; prostaglandins and cytotoxic drugs; chemotherapeutic agents; and estrogens.
    [0040] Other examples of suitable therapeutic agents, which can be included in any one or more than one of the supporting layer or substrate, absorbent pad, adhesive layer, and the non-sticky film include viruses and cells; peptides, polypeptides and proteins, as well as analogs, muteins, and active fragments thereof; immunoglobulins; antibodies; cytokines such as lymphokines; monocines and chemokines; blood clotting factors; hematopoietic factors; interleukins such as IL-2, IL3, IL-4 and IL-6; interferons such as β-IFN, α-IFN and γ-IFN; erythropoietin; nucleases; tumor necrosis factor; colony stimulating factors such as GSCF, GM-CSF, and MCSF; insulin; antitumor and tumor suppressive agents; blood proteins such as fibrin, thrombin, fibrinogen, synthetic thrombin, synthetic fibrin, synthetic fibrinogen; gonadotropins such as FSH,
    Petition 870190061452, of 7/1/2019, p. 29/41
    21/27
    LH and CG; hormones and hormone analogues such as growth hormone; vaccines such as tumor, bacterial and viral antigens; somatostatin; antigens; blood clotting factors, growth factors such as nerve growth factor and insulin-like growth factor; bone morphogenic proteins; TGF-B; protein inhibitors; protein antagonists; protein agonists; nucleic acids, such as antisense molecules, DNA, RNA, RN Ai; oligonucleotides; polynucleotides; and ribozymes.
    [0041] Anti-adhesive agents can be used to prevent adhesions from forming between the bandage and the wound or tissue surrounding the wound. Some examples of such agents include, but are not limited to, hydrophilic polymers such as poly (vinyl pyrrolidone), carboxymethyl cellulose, hyaluronic acid, polyethylene oxide, polyvinyl alcohols, and combinations thereof.
    [0042] An adhesive material or adhesive layer can be used to adhere the absorbent pad to the support material and, in some cases, to fix the adhesive bandage or bandage to the user's skin. The adhesive can be an aqueous solvent-based compound. In other configurations, the adhesive may be a non-aqueous solvent-based compound. In some cases, the adhesive material may comprise amorphous polyolefins that include amorphous polypropylene, ethylene copolymers such as ethylene vinyl acetate copolymers, and combinations thereof. Suitable adhesives also include adhesives based on acrylic, based on dextrin and based on urethane, as well as natural and synthetic elastomers, and mixtures thereof. In still other cases, the adhesive material can be a hot-melt material. Examples of suitable adhesive materials include, but are not limited to, those based on styrenic block copolymers and handle-forming resins. The adhesives may also include one or more of the tacking agents, antioxidants and processing oils. Commercially available adhesive component sources include Kraton Performance Polymers Inc., Houston, Texas; Η. B. Fuller Company, St. Paul, Minnesota; Bostik Inc., Wauwatosa, Wisconsin; National Starch, Bridgewater, New Jersey; and REXtac,
    Petition 870190061452, of 7/1/2019, p. 30/41
    22/27
    LLC, Odessa, Texas.
    [0043] The adhesive can be applied in any desired manner, such as spraying, screen printing, or notching matrix coating in the appropriate amount. The weight of the adhesive coating can vary can vary from about 20 grams per square meter (gsm) to about 100 gsm. In embodiments of the invention, the adhesive can be applied to a permeable support layer in an amount that maintains the permeability of the support layer or substrate. For example, a support layer composed of woven or non-woven fibers may have a desired porosity between the fibers before applying the adhesive and after applying the adhesive. In other embodiments of the invention, the adhesive can be applied in an amount that makes the porous support layer impermeable to fluids.
    [0044] Any of the dressings and bandages as described here can have any geometric configuration and any suitable dimension. For example, the dressing or bandages can be square, rectangular, round, oval or triangular. The size of the bandage or bandage will depend on the shape of the bandage or bandage and the size of the wound that is intended to be covered by the bandage or bandage. A square bandage can vary in size from about 2cm x 2cm to about 15cm x 15cm. A rectangular bandage can vary in size from about 5 cm to about 15 cm, in some cases, from about 1 cm to about 3 cm.
    [0045] The dressing or bandage can have any desired thickness, depending on the application or use. Typically, the thickness of the dressing or bandage can vary from about 0.25mm to about 5mm; in some embodiments of the invention, the thickness can vary from about 1 mm to about 3 mm; and in some other embodiments of the invention, the thickness can vary from about 1 mm to about 2 mm.
    [0046] Figures 1 and 2 illustrate as an example a dressing according to some aspects of the invention. The adhesive bandage may comprise a support substrate 20 affixed to an absorbent pad 40 via a
    Petition 870190061452, of 7/1/2019, p. 31/41
    23/27 adhesive 30. The adhesive 30 is shown positioned along the entire length of the supporting substrate 20; however, it is envisaged that adhesive 30 may be positioned along any portion of the appropriate support substrate, for example, to adhere the dressing as an adhesive bandage to the skin or fabric. The non-sticky film 50 may comprise a first polymeric material and a second polymeric material having a lower melting point than the first polymeric material. The non-sticky film 50 can be affixed to the wound-facing side or surface of the absorbent pad 40. The non-sticky film 50 can be a film that includes a mixture of a polyester and an amorphous polyester in which the amorphous polyester exhibits a lower melting than the first polyester material.
    [0047] As shown exemplarily in Figures 3 and 4, a dressing 100 may comprise an absorbent pad 140, which can optionally be attached to a support substrate (not shown) via an adhesive. The absorbent pad 140 may be positioned to be generally centralized along the entire length of the supporting substrate or along any part thereof. The non-sticky film may comprise a first and a second polymeric layer. As illustrated by way of example, the second polymeric layer 150a can be affixed to the wound-facing surface of the absorbent pad 140 and a first polymeric layer 150b of the non-sticky film can be attached to the second polymeric layer 150a. The polymeric material of the second polymeric layer 150a has a lower melting point than the polymeric material of the first polymeric layer 150b. In some embodiments of the invention, the second polymeric layer may comprise, consist essentially of, or consist of a different polyester, such as at least partially crystalline polyester.
    [0048] The dressing or bandages of the present invention can be of any shape or size suitable for covering a wound. As illustrated exemplarily in Figures 5 and 6, the adhesive bandage 200 can be
    Petition 870190061452, of 7/1/2019, p. 32/41
    24/27 an isolated and / or circular bandage with absorbent pad 240 affixed to a generally central portion of the support substrate 220 via, for example, an adhesive 230. As shown in FIG. 6, the non-sticky film 250 may have a first layer 250b which is attached or affixed to the absorbent pad 240 via a second layer 250a of the non-sticky film approximately around an outer perimeter of the absorbent pad 240. The second layer 250a typically has a melting point lower than the melting point of the first polymeric layer 250b. In such an embodiment, the first non-sticky film 250a can create an opening or channel between the second layer 250b and the absorbent pad 240 to allow wound exudates to flow during the wound healing process. Because the second polymeric layer 250a is advantageously positioned along the outer perimeter of the absorbent pad 240, the second polymeric layer 250a would probably not interfere with the absorption of wound exudates or other fluid through the central portion of the absorbent pad 240. The film does not sticky may have one or more perforated regions 260, each of which may have a plurality of perforations or openings 270 through the thickness of the film.
    [0049] The dressings and bandages of the present invention can be manufactured by providing a strip of support substrate having the desired dimensions, and optionally applying an adhesive to it. Typically an absorbent pad is provided. Optionally, the absorbent pad can be adhered to a desired region of the support substrate. A non-sticky film may be attached to the absorbent pad by at least partial melting or softening of a polymeric layer of the non-sticky film, by positioning the non-sticky film at least partially melted or softened in the absorbent pad; and optionally by applying pressure to discard at least a part of the molten or softened matrix in the absorbent pad. Release strips, such as paper with silicone, can optionally be placed over the
    Petition 870190061452, of 7/1/2019, p. 33/41
    25/27 exposed portions of the region where adhesive is applied as well as on the non-sticky film. The bandage is then wrapped, for example, by wrapping it between two layers of heat sealable paper, and heat sealing the periphery of the two layers of paper. The packaged bandage can then be sterilized, if desired. Upon use, the absorbent pad, the non-sticky film, or both, can be immersed in a bath comprising the therapeutic agent or agents. You can then let the wet pads dry.
    [0050] The absorbent pad may be made of a non-woven blend of fibers including viscose fibers, representing about 80% by weight of the pad and a polyester fiber representing about 20% by weight of the pad. The absorbent pad may initially be formed into long strips or rolls suitable for cutting into a plurality of smaller absorbent pads. The long strips or rolls of pads can then be passed through a solution containing a therapeutic agent, for example, an antimicrobial agent such as PHMB.
    [0051] The composite assembly comprising the absorbent pad and the non-sticky film can then be cut to a desired size.
    [0052] It will be understood that several modifications can be made in the modalities disclosed here. For example, the adhesive bandage can be an absorbable bandage. In another example, the adhesive bandages described here can be sterilized using any appropriate sterilization process, such as gamma radiation, and packaged in any suitable medical device package, such as an injectable medical device package. Thus, those skilled in the art can foresee other changes within the scope and spirit of the claims. Those skilled in the art should consider that the parameters and configurations described are exemplary and that the effective parameters and / or configurations will depend on the specific application in which the systems and techniques of the invention are used. For example, a single non-sticky film can be used to wrap any
    Petition 870190061452, of 7/1/2019, p. 34/41
    26/27 or the absorbent pads described here, with the non-sticky film having a plurality of regions or polymeric layers with different melting points, melting bands or softening points, and with the absorbent pad having one or more layers or regions, each of which may have different characteristics, and each of the various polymeric layers of the non-sticky film is a polyester with different melting bands and each layer of the absorbent pad uses 100% cotton fibers. Those skilled in the art must also recognize or be able to determine, using only routine experiments, equivalent to the specific modalities of the invention. It should, therefore, be understood that the modalities described here are presented by way of example only and that, within the scope of the appended and equivalent claims, the invention may be practiced in a manner different from that specifically described.
    [0053] Furthermore, it should be appreciated that the invention is directed to each characteristic, system, subsystem, set, or subset, or technique described here and any combination of two or more characteristics, systems, subsystems, set, subset, or techniques described herein, if such characteristics, systems, subsystems, assembly, subset, and techniques are not mutually inconsistent, it is considered to be within the scope of the invention as embodied in the claims. Furthermore, acts, elements, and characteristics discussed only in connection with one modality are not intended to be excluded from a similar role in other modalities.
    [0054] As used here, the term "plurality" refers to two or more items or components. The use of ordinal terms, such as "first", "second", "third" in claims to modify an element in the claim does not carry with it any connotation of priority, precedence, or order of one element of the claim over another or the order time in which acts of a method are performed, but they are used merely as indicators to distinguish an element of the claim having a given
    Petition 870190061452, of 7/1/2019, p. 35/41
    27/27 another element having the same name, except for the use of the term ordinal, to distinguish the elements in the claim. The terms "comprising", "including", "bearing", "having", "containing", and "involving", whether in the written description or in the claims, are terms open to interpretation. Thus, the use of these terms is intended to cover the items listed below, and equivalents thereof, as well as additional items. Only the transition expressions "consisting of" and "consisting essentially of" are restricted or semi-restricted transition expressions, respectively, with respect to the claims.
    权利要求:
    Claims (14)
    [1]
    1. Dressing for application to a wound, characterized by the fact that:
    an absorbent pad having a wound-facing surface and a second surface opposite the wound-facing surface, wherein the absorbent pad consists essentially of cellulosic fibers and polymeric fibers; and a non-sticky film attached to the absorbent pad on the wound-facing surface, the non-sticky film having a first region comprising a first polymeric material and a second region comprising a second polymeric material having a lower melting point than that of the first material polymeric, wherein the second polymeric material comprises an amorphous polymer, polyethylene terephthalate, having a melting temperature range between 120 ° C to 200 ° C, with a glass transition temperature in a range of 60 ° C to 88 ° C , and wherein the first polymeric material comprises polyethylene terephthalate having a melting temperature range in the range of 200 ° C to 275 ° C, and in which the absorbent pad comprises polyhexamethylene biguanide.
    [2]
    2. Dressing according to claim 1, characterized by the fact that the first polymeric material comprises a first thermoplastic polymer selected from the group consisting of polypropylene, vinylidene polyfluoride, polytetrafluoroethylene, vinyl chloride, polyamide, polyethylene, polyvinyl alcohol, polyester, polystyrene, polymethylpentene, polyoxymethylene, and mixtures thereof, wherein the second polymeric material comprises a second thermoplastic polymer selected from the group consisting of polypropylene, vinylidene polyfluoride, polytetrafluoroethylene, polyvinyl chloride, polyamide, polyethylene, polyvinyl alcohol, polyester , polystyrene, polymethylpentene, polyoxymethylene, and mixtures thereof; and where the second region defines a fixing layer that holds the non-sticky film on the surface facing the
    Petition 870190061452, of 7/1/2019, p. 37/41
    2/4 injury to the absorbent layer.
    [3]
    3. Dressing according to claim 1 or 2, characterized in that the first polymeric material consists essentially of a first polyester and the second polymeric material consists essentially of a second polyester.
    [4]
    4. Dressing according to any one of claims 1 to 3, characterized in that it further comprises a second film attached to the absorbent pad on its second surface, the second film having a third region comprising the first polymeric material and a fourth region comprising the second polymeric material, and in which the fourth region defines a second fixing layer which secures the second film to the second surface of the absorbent pad.
    [5]
    Dressing according to any one of claims 1 to 4, characterized by the fact that it also comprises a supporting substrate having an adhesive material on a surface thereof.
    [6]
    6. Dressing according to claim 5, characterized by the fact that the supporting substrate comprises a woven cloth and the adhesive material comprises an acrylic.
    [7]
    7. Dressing according to any one of claims 1 to 6, characterized in that the non-sticky film has a perforated region including a plurality of perforations that extend through the thickness of the film, and in which cellulosic fibers are selected from the group consisting of viscose, cotton, paper pulp in fiber, lyocell, and combinations thereof, and polymeric fibers are selected from the group consisting of polypropylene fibers, polyester fibers, and combinations thereof.
    [8]
    Dressing according to any one of claims 1 to 7, characterized in that the absorbent pad has a first absorbent layer comprising a low density absorbent cloth and a second conduction layer comprising a high absorbent cloth
    Petition 870190061452, of 7/1/2019, p. 38/41
    3/4 density.
    [9]
    9. Method of producing a wound dressing as defined in any one of claims 1 to 8, characterized by the fact that it comprises:
    providing a non-sticky film having a first region comprising a first polymeric material and a second region comprising a second polymeric material with a lower melting point than the first polymeric material, wherein the absorbent pad consists essentially of cellulosic fibers and polymeric fibers.
    [10]
    Method according to claim 9, characterized in that providing the non-sticky film having the first region comprising the first polymeric material and the second region comprising the second polymeric material comprises providing the first polymeric material having a melting range ranging from 200 ° C to 275 ° C, and providing the second polymeric material having a melting range ranging from 120 ° C to 200 ° C.
    [11]
    11. Method according to claim 9 or 10, characterized in that fixing the non-sticky film to the absorbent pad comprises exposing the non-sticky film to an environment with a temperature in the range of 140 ° C to 200 ° C.
    [12]
    12. Method according to any of claims 9 to 11, characterized by the fact that it further comprises:
    immerse at least part of the absorbent pad in a fluid comprising polyhexamethylene biguanide to produce a pad immersed in PHMB; and drying the pad immersed in PHMB to produce a pad containing PHMB; and wherein fixing the non-sticky film to the absorbent pad comprises fixing the second region of the non-sticky film to the pad containing PHMB.
    Petition 870190061452, of 7/1/2019, p. 39/41
    4/4
    [13]
    13. Dressing according to claim 1, characterized by the fact that the absorbent pad consists essentially of a mixture of 80% by weight of viscose fibers and 20% by weight of polyester fibers.
    [14]
    14. Dressing according to claim 9, characterized in that the absorbent pad essentially consists of a mixture of 80% by weight of viscose fibers and 20% by weight of polyester fibers.
    类似技术:
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    同族专利:
    公开号 | 公开日
    CN103596598B|2015-11-25|
    WO2012170334A4|2013-05-02|
    CN103596598A|2014-02-19|
    AU2012268574B2|2014-09-11|
    EP2717931A4|2015-01-07|
    CA2838065C|2016-08-30|
    MX370013B|2019-11-28|
    WO2012170334A3|2013-03-14|
    MX2013013780A|2014-01-08|
    EP2717931A2|2014-04-16|
    WO2012170334A2|2012-12-13|
    US20120310186A1|2012-12-06|
    AU2012268574A1|2013-12-12|
    CA2838065A1|2012-12-13|
    BR112013031188A2|2017-01-31|
    EP2717931B1|2019-08-07|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    BE795478A|1972-02-16|1973-08-16|Cellophane Sa|COMPOSITE FILMS OF POLYESTERS AND THEIR MANUFACTURING PROCESS|
    FR2471184B1|1979-12-10|1986-06-27|Tempo Sanys|STERILIZABLE SURGICAL BUFFER AND DEVICE FOR THE CONTINUOUS MANUFACTURE OF SUCH A BUFFER|
    US4590114A|1984-04-18|1986-05-20|Personal Products Company|Stabilized absorbent structure containing thermoplastic fibers|
    DK398884D0|1984-08-21|1984-08-21|Coloplast As|INCONTINENCE PROTECTION AND PROCEDURE FOR MANUFACTURING THIS|
    US5318552A|1986-12-10|1994-06-07|Kao Corporation|Absorbent article having an improved non-woven fabric layer|
    DK5492A|1992-01-17|1993-07-18|Coloplast As|A dressing|
    US5505719A|1994-06-30|1996-04-09|Mcneil-Ppc, Inc.|Multilayered absorbent structures|
    US5632731A|1994-11-25|1997-05-27|The Kendall Company|Non-adherent wound dressing|
    US5667864A|1995-06-07|1997-09-16|Landoll; Leo M.|Absorbant laminates and method of making same|
    US20010023159A1|1995-11-13|2001-09-20|First Brands Corporation|Absorbent pad|
    US5843057A|1996-07-15|1998-12-01|Kimberly-Clark Worldwide, Inc.|Film-nonwoven laminate containing an adhesively-reinforced stretch-thinned film|
    US6162961A|1998-04-16|2000-12-19|Kimberly-Clark Worldwide, Inc.|Absorbent article|
    US20060039958A1|2003-05-28|2006-02-23|Monosolrx, Llc.|Multi-layer films having uniform content|
    US20050054998A1|2003-09-05|2005-03-10|Poccia John F.|Absorbent article|
    BRPI0404697A|2004-10-26|2006-06-13|Johnson & Johnson Ind Ltda|dressing product and method for manufacturing a dressing product|
    CA2674876A1|2007-01-10|2008-07-17|Polyremedy, Inc.|Wound dressing with controllable permeability|
    AU2009286021B2|2008-08-28|2014-07-17|Covidien Lp|Environmentally activated compositions, articles and methods|
    EP2323480A4|2008-08-28|2013-02-27|Covidien Lp|Antimicrobial foam compositions, articles and methods|
    WO2010051256A1|2008-10-27|2010-05-06|Sessions Pharmaceuticals Inc.|Fluid extracting wound dressing|
    US8147957B2|2009-01-27|2012-04-03|Milliken & Company|Consolidated fibrous structure|
    US8119549B2|2009-01-27|2012-02-21|Milliken & Company|Consolidated fibrous structure|
    US8850719B2|2009-02-06|2014-10-07|Nike, Inc.|Layered thermoplastic non-woven textile elements|
    CN102387919A|2009-04-08|2012-03-21|宝洁公司|Stretchable laminates of nonwoven web and elastic film|CA2949821C|2005-09-06|2021-05-18|Smith & Nephew, Inc.|Self contained wound dressing with micropump|
    EP2345437B1|2008-03-05|2014-04-23|KCI Licensing, Inc.|Dressing for applying reduced pressure to and collecting and storing fluid from a tissue site|
    WO2011017532A2|2009-08-05|2011-02-10|International Paper Company|Process for applying composition containing a cationic trivalent metal and debonder and fluff pulp sheet made from same|
    BR122020024226B1|2009-08-05|2021-09-08|International Paper Company|PROCESS TO PREPARE A PLUFFY PULP SHEET|
    MY162376A|2009-08-05|2017-06-15|Shell Int Research|Method for monitoring a well|
    CN103003488B|2010-07-22|2015-04-15|国际纸业公司|Process for preparing fluff pulp sheet with cationic dye and debonder surfactant and fluff pulp sheet made from same|
    CN105963074B|2011-07-14|2020-01-17|史密夫及内修公开有限公司|Wound dressing and method of treatment|
    US10940047B2|2011-12-16|2021-03-09|Kci Licensing, Inc.|Sealing systems and methods employing a hybrid switchable drape|
    CN105726211B|2011-12-16|2020-04-28|凯希特许有限公司|Releasable medical drape|
    EP3354293B1|2012-05-23|2019-12-11|Smith & Nephew plc|Apparatuses for negative pressure wound therapy|
    AU2013298195B2|2012-08-01|2017-07-13|Smith & Nephew Plc|Wound dressing|
    US10076449B2|2012-08-01|2018-09-18|Smith & Nephew Plc|Wound dressing and method of treatment|
    EP3092990B1|2012-11-16|2020-03-11|KCI Licensing, Inc.|Method of manufacturing a medical drape with pattern adhesive layers|
    KR20160024972A|2013-06-27|2016-03-07|쓰리엠 이노베이티브 프로퍼티즈 캄파니|Composite polymeric layers and methods of making the same|
    WO2015065742A1|2013-10-28|2015-05-07|Kci Licensing, Inc.|Hybrid sealing tape|
    EP3744361A1|2013-10-30|2020-12-02|KCI Licensing, Inc.|Absorbent conduit and system|
    EP3656362A1|2013-10-30|2020-05-27|KCI Licensing, Inc.|Condensate absorbing and dissipating system related application|
    US9956120B2|2013-10-30|2018-05-01|Kci Licensing, Inc.|Dressing with sealing and retention interface|
    EP3173054B1|2013-10-30|2018-04-25|KCI Licensing, Inc.|Dressing with diffrentially sized perforations|
    CA2940730A1|2014-02-28|2015-09-03|Kci Licensing, Inc.|Hybrid drape having a gel-coated perforated mesh|
    US11026844B2|2014-03-03|2021-06-08|Kci Licensing, Inc.|Low profile flexible pressure transmission conduit|
    EP3854361A1|2014-06-05|2021-07-28|3M Innovative Properties Company|Dressing with fluid acquisition and distribution characteristics|
    CA2952284A1|2014-06-18|2015-12-23|Smith & Nephew Plc|Wound dressing|
    EP3294245B1|2015-05-08|2019-09-04|KCI Licensing, Inc.|Low acuity dressing with integral pump|
    US11096830B2|2015-09-01|2021-08-24|Kci Licensing, Inc.|Dressing with increased apposition force|
    US10973694B2|2015-09-17|2021-04-13|Kci Licensing, Inc.|Hybrid silicone and acrylic adhesive cover for use with wound treatment|
    US20180353640A1|2015-11-24|2018-12-13|University Of Washington|Photosensitive Medical Tape|
    CN105497965A|2015-12-29|2016-04-20|泰安市飞虹麻丝制品科技有限公司|Sustained drug release type medicine dressing|
    US20200107962A1|2018-10-04|2020-04-09|Milliken & Company|Medical device containing a multi-ply knit fabric|
    US20200107963A1|2018-10-04|2020-04-09|Milliken & Company|Wound dressing system|
    法律状态:
    2018-01-02| B25A| Requested transfer of rights approved|Owner name: KPR U.S., LLC (US) |
    2018-01-23| B07D| Technical examination (opinion) related to article 229 of industrial property law|
    2018-04-03| B06F| Objections, documents and/or translations needed after an examination request according art. 34 industrial property law|
    2018-05-15| B07B| Technical examination (opinion): publication cancelled|
    2019-01-15| B06T| Formal requirements before examination|
    2019-04-02| B07A| Technical examination (opinion): publication of technical examination (opinion)|
    2019-08-13| B09A| Decision: intention to grant|
    2019-10-01| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 04/06/2012, OBSERVADAS AS CONDICOES LEGAIS. (CO) 20 (VINTE) ANOS CONTADOS A PARTIR DE 04/06/2012, OBSERVADAS AS CONDICOES LEGAIS |
    优先权:
    申请号 | 申请日 | 专利标题
    US13/153,842|US20120310186A1|2011-06-06|2011-06-06|Dressings and Related Methods Therefor|
    US13/153,842|2011-06-06|
    PCT/US2012/040697|WO2012170334A2|2011-06-06|2012-06-04|Dressings and related methods therefor|
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